Langerhans cell histicytosis (LCH) is a rare disorder that primarily affects children. Its occurrence in adult is very rare. We report a case of 42 year old female patient who presented polyuria and polydipsia, loosing teeth and diplopia added to symptom .The diagnostic workup revealed endocrine involvement with diabetes insipidus. The x ray Orthopantomogram (OPG) showed destructive bone lesion of mandible. Biopsy of lesion revealed histiocytosis X. We herein describe the case report of Langerhans cell histiocytosis on mandible and involvement endocrine system.

Key words: Langerhans cell histicytosis (LCH); Diabetes insipidus (DI); Mandibular lesion  
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