Introduction: Smoking is a major risk factor in the genesis of coronary atherosclerosis and development of coronary heart disease. Smoking may alter normal plasma lipoprotein levels. The present study was undertaken to compare the lipid profile between non- smokers (Group A) and chronic smokers (Group B) and also between chronic smokers (Group B) and chronic smokers with acute myocardial infarction (AMI) (Group C).

Methods: Thirty six apparently healthy non- smokers, 36 apparently healthy chronic smokers and 36 chronic smokers with AMI were selected for the study. Fasting venous blood samples were collected; triglycerides (TG), total cholesterol (TC) and high density lipoprotein cholesterol (HDL-C) were measured. Low-density lipoprotein cholesterol (LDL-C) and very low-density lipoprotein cholesterol (VLDL-C) were calculated by Friedwald’s formula.

Results: The lipid profile was compared between Group A and   Group B and also between Group B and Group C. There was a significant rise in TG, TC, LDL-C, VLDL-C and significant decrease in HDL-C in Group B compared to Group A. There was a significant rise in TG, TC, LDL-C, VLDL-C and significant decrease in HDL-C in Group C compared to   Group B.

Conclusion: Smoking increases the risk of atherosis and smoking modulates the ischemic heart disease risk through gene-environment interaction. Further studies are required to ascertain the gene environment interaction.

Key words: Non-smokers; Chronic smokers; Acute myocardial infarction; Lipid profile  
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