Abstract

Introduction: Smoking is a major risk factor in the genesis of coronary atherosclerosis and development of coronary heart disease. Smoking may alter normal plasma lipoprotein levels. The present study was undertaken to compare the lipid profile between non- smokers (Group A) and chronic smokers (Group B) and also between chronic smokers (Group B) and chronic smokers with acute myocardial infarction (AMI) (Group C).

Methods: Thirty six apparently healthy non- smokers, 36 apparently healthy chronic smokers and 36 chronic smokers with AMI were selected for the study. Fasting venous blood samples were collected; triglycerides (TG), total cholesterol (TC) and high density lipoprotein cholesterol (HDL-C) were measured. Low-density lipoprotein cholesterol (LDL-C) and very low-density lipoprotein cholesterol (VLDL-C) were calculated by Friedwald’s formula.

Results: The lipid profile was compared between Group A and   Group B and also between Group B and Group C. There was a significant rise in TG, TC, LDL-C, VLDL-C and significant decrease in HDL-C in Group B compared to Group A. There was a significant rise in TG, TC, LDL-C, VLDL-C and significant decrease in HDL-C in Group C compared to   Group B.

Conclusion: Smoking increases the risk of atherosis and smoking modulates the ischemic heart disease risk through gene-environment interaction. Further studies are required to ascertain the gene environment interaction.

Key words: Non-smokers; Chronic smokers; Acute myocardial infarction; Lipid profile  
 
 
» HTML Fulltext    » PDF Fulltext    » doi: 

Latest Issue:

In October-December 2018, the journal publishes several original research, including an outstanding Prospective Cohort Study, some experimental studies, and an editorial on a topic of current interest in today’s medical research. Read more:


 

The 6th World Conference on Research Integrity (WCRI) is to be held on June 2-5, 2019 in Hong Kong.

The WCRI is the largest and most significant international conference on research integrity. Since the first conference in Lisbon in 2007, it has given researchers, teachers, funding agencies, government officials, journal editors, senior administrators, and research students opportunities to share experiences and to discuss and promote integrity in research. Read more:


 

TDR Clinical Research and Development Fellowships

Call for applications

Deadline for submission: 7 March 2019, 16:00 (GMT)

TDR provides fellowships for early- to mid-career researchers and clinical trial staff (e.g. clinicians, pharmacists, medical statisticians, data managers, other health researchers) in low- and middle-income countries (LMICs) to learn how to conduct clinical trials. Read more:


Meta-Analysis Workshops in New York, USA, and London, UK, in April and May 2019

Don't miss this exceptional opportunity to learn how to perform and report a Meta-analysis correctly. Two Meta-analysis workshops are organized in April and May 2019 by Dr. Michael Borenstein in New York, USA (April 08-10, 2019) and London, UK (May 27-29).

About the Instructor

Dr. Michael Borenstein, one of the authors of Introduction to Meta-Analysis, is widely recognized for his ability to make statistical concepts accessible to researchers as well as to statisticians. He has lectured widely on meta-analysis, including at the NIH, CDC, and FDA. Read more: